Giorgio Persano opened his first gallery, Multipli, in 1970. While interested in American pop graphics, he began producing multiplied works by Italian artists, such as Michelangelo Pistoletto, Gilberto Zorio, Alighiero Boetti, Pier Paolo Calzolari, Giovanni Anselmo, Salvo, Giuseppe Penone and Giulio Paolini. Since 1975, some of them have begun to use the gallery space as a workshop, creating installations and experimenting with new creative processes. Since then, Persano has taken care of the projects and productions of the works by establishing a close collaboration with his artists.

Over the years, he has worked with Michelangelo Pistoletto, Mario Merz, Pier Paolo Calzolari, Jannis Kounellis, Nicola De Maria, Emilio Prini, Gilberto Zorio, Joseph Kosuth, Sol LeWitt, Max Neuhaus, Lawrence Weiner, Franz West, Jan Dibbets, Bernar Venet, Pedro Cabrita Reis, Julião Sarmento, Susana Solano, Costas Varotsos, Avery Preesman, Susan Norrie, Susy Gómez, Lida Abdul, Alfredo Romano, Michele Zaza, Luisa Rabbia, Herbert Brandl, Per Barclay, Marco Bagnoli, Marco Gastini, Alessandro Sciaraffa, Lina Fucà, Michael Biberstein, Zena el Khalil, Paolo Cirio, Nunzio.