The gallery was founded in 1966 by Daniel Templon, who was then only 21. It first opened rue Bonaparte, in Saint-Germain-des-Prés in Paris, before moving in 1972 to its current location, rue Beaubourg, in the Marais, close to the Pompidou Center, which opened in 1977. Daniel Templon first gained recognition by exhibiting conceptual and minimal artists such as Martin Barré, Christian Boltanski, Donald Judd, Joseph Kosuth, Richard Serra. In the seventies and eighties, Daniel Templon was one of the pioneers of the contemporary art and introduced many important American artists to the French public including, Willem de Kooning, Frank Stella, and Andy Warhol, among others. The gallery quickly became one of the references in contemporary art in France. In 1972, Daniel Templon and Catherine Millet co-founded the monthly art magazine Art Press.
Over the years, many artists now part of art history have exhibited with the gallery: Martin Barré, Christian Boltanski, Joseph Kosuth, Ben, Arman, César, Carl Andre, Dan Flavin, Sol LeWitt, Frank Stella, Olivier Mosset, Roy Lichtenstein, Andy Warhol, Karel Appel, Willem de Kooning, Helmut Newton, Francesco Clemente, Julian Schnabel, Daniel Buren, Jean-Michel Basquiat, David Salle, Robert Mapplethorpe, Robert Rauschenberg, Joel Shapiro, Georg Baselitz, Richard Long, William Eggleston, Hiroshi Sugimoto, Yayoi Kusama, Richard Deacon, Larry Bell, Guillermo Kuitca, Anthony Caro, among many others.
Today, Galerie Templon represents a group of international artists, many of whom have participated in international exhibitions such as the Venice Biennale, Documenta, the Whitney Biennale, et al. The gallery participates in art fairs worldwide, including FIAC since 1974 and Art Basel since 1978.